7-Keto DHEA

Uses

7-KETO (3-acetyl-7-oxo-dehydroepiandrosterone) is a naturally occurring metabolite (breakdown product) of the hormone dehydroepiandrosterone (DHEA).1 DHEA is the most abundant of the adrenal steroid hormones and serves as a precursor for sex hormones, such as estrogen and testosterone.

What Are Star Ratings?

This supplement has been used in connection with the following health conditions:

Used for Why
2 Stars
Obesity
100 mg twice per day
7-Keto DHEA was found in a single randomized controlled trial to promote weight loss in people with overweight and obesity.
7-Keto DHEA (3-acetyl-7-oxo-dehydroepiandrosterone) is a derivative of DHEA that may influence hormone signaling related to fat production and distribution. 7-Keto DHEA was found to promote weight loss in in one double-blind placebo-controlled trial. The trial included 30 participants with overweight or obesity who engaged in a cross-training exercise program for 60 minutes three times per week, were instructed to eat a diet providing 1,800-calories per day, and were given either 100 mg of 7-keto DHEA or placebo twice daily. After eight weeks, those receiving 7-keto DHEA had lost more weight and lowered their percentage of body fat more than those taking a placebo. In addition, they had increased levels of active thyroid hormone (triiodothyronine or T3), which plays a major role in determining metabolic rate.

How It Works

How to Use It

The manufacturer of 7-KETO recommends 100 mg twice daily for weight loss.

Where to Find It

7-KETO is available as a dietary supplement.

Possible Deficiencies

Since the level of 7-KETO is directly related to the level of DHEA in the body,2 people with lower DHEA levels likely have low 7-KETO levels as well. Low DHEA levels are primarily associated with aging.

Interactions

Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers' package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Side Effects

A safety study in humans has shown that 7-KETO did not raise estrogen or testosterone levels or produce any other negative effects at levels up to 200 mg per day for eight weeks.3 Short-term animal studies also revealed no adverse effects with large amounts of 7-KETO.4 , 5 , 6 However, the long-term safety of 7-KETO for humans has not been demonstrated, and, because it is chemically related to steroid hormones, the potential for adverse effects must be considered. In addition, the increase in T3 levels resulting from taking 7-KETO could, in theory, produce adverse effects on the heart or promote bone loss. For these reasons, people wishing to take 7-KETO, particularly those who have a thyroid disorder or are taking thyroid hormone, should consult a physician.

References

1. Lardy H, Kneer N, Wei Y, et al. Ergosteroids. II: Biologically active metabolites and synthetic derivatives of dehydroepiandrosterone. Steroids 1998;63:158-65.

2. Lardy H, Kneer N, Wei Y, et al. Ergosteroids. II: Biologically active metabolites and synthetic derivatives of dehydroepiandrosterone. Steroids 1998;63:158-65.

3. Davidson MH, Weeks CE, Lardy H, et al. Safety and endocrine effects of 3-acetyl-7-oxo DHEA (7-keto DHEA). FASEB J 1998;12:A4429.

4. Lardy H, Henwood SM, Weeks CE. An acute oral gavage study of 3beta-acetoxyandrost- 5-ene-7,17-dione (7-oxo-DHEA-acetate) in rats. Biochem Biophys Res Commun 1999;254:120-3.

5. Henwood SM, Weeks CE, Lardy H. An escalating dose oral gavage study of 3beta-acetoxyandrost-5-ene-7, 17-dione (7-oxo-DHEA-acetate) in rhesus monkeys. Biochem Biophys Res Commun 1999;254:124-6.

6. Weeks C, Lardy H, Henwood S. Preclinical toxicology evaluation of 3-acetyl-7-oxo-dehydroepiandrosterone (7-keto DHEA). FASEB J 1998;12:A4428.