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Wild Yam


Botanical names:
Dioscorea villosa

Parts Used & Where Grown

Wild yam plants are found across the midwestern and eastern United States, Latin America (especially Mexico), and Asia. Several different species exist. All of which possess similar constituents and properties. The root is used medicinally.

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Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

3 StarsReliable and relatively consistent scientific data showing a substantial health benefit.

2 StarsContradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

1 StarFor an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

This supplement has been used in connection with the following health conditions:

Used forWhy
1 Star
High Cholesterol
Refer to label instructions
Wild yam has been reported to raise HDL (“good”) cholesterol in preliminary research.

has been reported to raise HDL cholesterol in preliminary research. Doctors sometimes recommend 2 to 3 ml of tincture taken three to four times per day, or 1 to 2 capsules or tablets of dried root taken three times per day.

1 Star
Refer to label instructions
Wild yam is an herb with weak estrogen-like actions similar to soy. In one trial, a formula containing licorice, burdock, dong quai, wild yam, and motherwort reduced menopause symptoms.

A variety of herbs with weak estrogen-like actions similar to the effects of soy have traditionally been used for women with menopausal symptoms. These herbs include licorice, alfalfa, and red clover. In a double-blind trial, a formula containing tinctures of licorice, burdock, dong quai, , and motherwort (30 drops three times daily) was found to reduce symptoms of menopause. No effects on hormone levels were detected in this study. In a separate double-blind trial, supplementation with dong quai (4.5 grams three times daily in capsules) had no effect on menopausal symptoms or hormone levels. A double-blind trial using a standardized extract of subterranean clover (Trifolium subterraneum), a relative of red clover, containing 40 mg isoflavones per tablet did not impact symptoms of menopause, such as hot flashes, though it did improve function of the arteries. An extract of red clover, providing 82 mg of isoflavones per day, also was ineffective in a 12-week double-blind study. In another double-blind study, however, administration of 80 mg of isoflavones per day from red clover reduced the frequency of hot flashes in postmenopausal women. The benefit was noticeable after 4 weeks of treatment and became more pronounced after a total of 12 weeks.

Traditional Use (May Not Be Supported by Scientific Studies)

Wild yam has been used by herbalists as an expectorant for people with coughs. It was also used for gastrointestinal upset, nerve pain, and morning sickness.1 Eventually, it was discovered that the saponins from wild yam could be converted industrially into cortisone, estrogens, and progesterone-like compounds. Wild yam and other plants with similar constituents continue to be a source for these drugs.

How It Works

Botanical names:
Dioscorea villosa

How It Works

The steroidal saponins (such as diosgenin) account for some of the activity of wild yam. Another compound, dioscoretine, has been shown in animal studies to lower blood sugar levels.2 An extract of wild yam was also found in a clinical trial to have antioxidant properties and raised HDL, the “good,”cholesterol in elderly adults.3

Contrary to popular claims, wild yam roots do not contain and are not converted into progesterone or dehydroepiandrosterone (DHEA) in the body.4, 5 Pharmaceutical progesterone is made from wild yam using a chemical conversion process. This can lead to confusion—while wild yam can be a source of progesterone, it cannot be used without this pharmaceutical conversion, which cannot be duplicated by the body. Women who require progesterone should consult with their physician and not rely on wild yam supplements.

How to Use It

Up to 2–3 ml of wild yam tincture can be taken three to four times per day. Alternatively, 1 gram of dried, powdered root can be taken three times each day.6


Botanical names:
Dioscorea villosa

Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Botanical names:
Dioscorea villosa

Side Effects

Some people may experience nausea or vomiting when taking large amounts of wild yam (several times the recommended amounts). The safety of wild yam during pregnancy and breast feeding has not been established.

Related Information

Wild Yam
  1. What Are Depletions & Interactions?


1. Lust JB. The Herb Book. New York: Bantam Books, 1974, 401.

2. Iwu MM, Okunji CO, Ohiaeri GO, et al. Hypoglycaemic activity of dioscoretine from tubers of Dioscorea dumetorum in normal and alloxan diabetic rabbits. Planta Med 1990;56:264-7.

3. Araghiniknam M, Chung S, Nelson-White T, et al. Antioxidant activity of dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sci 1996;11:147-57.

4. Araghiniknam M, Chung S, Nelson-White T, et al. Antioxidant activity of dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sci 1996;11:147-57.

5. Dollbaum CM. Lab analyses of salivary DHEA and progesterone following ingestion of yam-containing products. Townsend Letter for Doctors and Patients Oct 1995:104.

6. Bertram T. Encyclopedia of Herbal Medicine. Dorset, England: Grace Publishers, 1995, 454.

Last Review: 04-14-2015

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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2022.

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