SAM-e is short for S-adenosylmethionine. It is found in the cells of plants, animals, and humans. SAM-e is available as a dietary supplement.
Some people take SAM-e supplements to improve symptoms of depression, osteoarthritis, or liver disease. SAM-e is also taken as a quit-smoking aid and for health problems like Alzheimer's disease, attention-deficit hyperactivity disorder (ADHD), fibromyalgia, and migraines. So far, there isn't clear proof from science that taking SAM-e helps with these or other health problems.
Not all herbs and supplements are safe. If you aren't sure about the safety of a supplement or herb, talk to your doctor, pharmacist, or dietitian.
Always tell your doctor if you are using a dietary supplement or if you're thinking about combining a supplement with your standard medical treatment. It may not be safe to stop your medical treatment and rely only on a supplement. This is even more important if you are pregnant or breastfeeding.
When using dietary supplements, keep these things in mind:
- They may cause side effects or trigger allergic reactions. They can also interact with prescription and nonprescription medicines or other supplements you might be taking. A side effect or interaction may make other health conditions worse.
- The way supplements are made may not be standardized. Because of this, how well they work or any side effects they cause may differ among brands or even within different lots of the same brand. The form of supplement that you buy in a store may not be the same as the form used in research.
- Other than for vitamins and minerals, the long-term effects of most supplements aren't known.
Current as of: September 8, 2022
Author: Healthwise Staff
Medical Review:
Adam Husney MD - Family Medicine
Kathleen Romito MD - Family Medicine